COAgulation Disorders in Ischaemic and Haemorrhagic Stroke

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorZiekenhuis Oost-Limburg

About this trial

In this study the investigators will assess both procoagulant and anticoagulant pathways using thrombin generation and platelet function tests; as well as neuronal ischemia using cell free DNA in all patients presenting with ischaemic and haemorrhagic stroke (including aneurysmal subarachnoid haemorraghe). Also the cross-talk between inflammation and thrombosis, so-called thrombo-inflammation is further investigated. As such the investigators aim to characterise the patient's coagulation profile before administration of any treatment. By assessing these pathways the investigators strive to detect specific markers to predict vital and functional outcome at 3 months in these patients. Finally the investigators may provide new pathophysiological insights in the course of disease following these events that can possibly improve future therapeutic strategies.

Eligibility criteria

Qualifiers

None

Disqualifiers

Refusal of participation by patient or legal representative

Traumatic intracranial (subdural, subarachnoid, epidural haematoma) bleeding

Patients receiving treatment with interference on coagulation (pro / anti) before first sampling: in this group of patients the coagulation assessment at presentation will be excluded, further lab sampling is performed according to protocol.

Patients categorized as having stroke mimic will be excluded from analysis afterwards

Trial design

Treatments tested in this trial

  • blood sampling

Treatment groups

350 Participants
are divided into 3 treatment groups

Sponsors and collaborators