Cognition and QoL After Thyroid Surgery

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorKarolinska University Hospital

About this trial

The development of cognitive dysfunction can profoundly affect HR-QoL as well as the possibility of societal participation and ability to work, and thereby relevantly impacts prospects for cancer survivorship. The aim of the study is to obtain improved understanding of the scope and magnitude of objective cognitive dysfunction in DTC survivors, and its relation to subjective cognitive dysfunction, thyroid hormone levels, physical activity and HRQoL. This is done in a prospective study where patients operated for a thyroid nodule (Bethesda IV-VI, i.e., benign \[goitre with nodule and fibroadenomas\], low-risk DTC and intermediate-high risk DTC) are included and asked to serially perform online neuropsychological testing as well as to complete questionnaires related to HR-QoL, physical activity and additional psychological and physical complaints. Blood is analysed for levels of thyroid hormones and systemic inflammation.

Eligibility criteria

Qualifiers

Age >18 years old, indication for surgery because of a thyroid nodule Bethesda IV-VI

Able to read and understand the Swedish language

Access to desktop computer or laptop with internet connection

Able and willing to provide written informed consent

Disqualifiers

A previous diagnosis of (auto-immune) hypothyroidism

A previous cancer diagnosis (excluding basal cell cancer of the skin)

Indications for surgery other than (solely) a thyroid nodule (i.e., concomitant Graves)

A diagnosis of medullary and anaplastic thyroid cancer

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

No trial groups listed

Sponsors and collaborators

Karolinska University Hospital

Lead sponsor

The Netherlands Cancer Institute

Collaborator