Cognition, Flavonoids, Exercise, Gut Microbiome
ConditionCognitive Decline, Mild
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-85
SponsorAppalachian State University
About this trial
This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants identified as experiencing age-related cognitive changes. This project's hypothesis is that the combination of flavonoid-rich diet and routine physical activity may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the gut microbiome.
Eligibility criteria
Qualifiers
Score on the Montreal Cognitive Assessment (MoCA test) of 24.1-25.2 that indicates mild cognitive decline. The MoCA test score ranges from 0 to 30, with higher scores from 26 to 30 considered normal.
Healthy, non-smoking male or female participants 65 to 85 years of age.
Capable of engaging in a supervised 12-week exercise training program (brisk walking or stretching).
Physically inactive (defined as less than 150 min/week moderate or less than 75 minutes vigorous aerobic and/or resistance exercise during the past 4 weeks).
Disqualifiers
Allergy to blueberries.
Diagnosis of Type I or Type 2 diabetes.
Chronic cardiovascular, metabolic, or renal condition that is uncontrolled (controlled defined as stable for 6 months or more).
History of signs or symptoms during rest or physical activity such as chest discomfort, unreasonable breathlessness, dizziness, fainting, or blackouts.
Trial design
Treatments tested in this trial
- Blueberry
- Walking
- Placebo
- Stretching
Treatment groups
240 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov