Cognitive and Vascular Functioning Following TBI
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-74
SponsorWalter Reed National Military Medical Center
About this trial
This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia. Cerebrovascular, inflammatory, and neurodegenerative blood biomarkers as well as clinical and neuroimaging data
Eligibility criteria
Qualifiers
Active duty uniformed SM or Veteran who is currently eligible for treatment at WRNMMC (i.e., Defense Enrollment Eligibility Reporting System (DEERS)-eligible).
Ability to read, write, and speak English.
Ability to provide informed consent.
NICoE Intensive Outpatient Program (IOP) or NatHx Study comprehensive evaluation ≥3 years prior to current evaluation with valid neuropsychological test results.
Disqualifiers
Disabling neurologic or psychological disorders such as autism, cerebral palsy, developmental disorder, stroke, brain tumor, multiple sclerosis, meningitis, encephalitis, brain abscess, vascular malformation, pre-injury epilepsy, schizophrenia, bipolar disorder, personality disorder
Diabetes mellitus requiring drug treatment
Hypertension requiring more than 1 antihypertensive drug to control BP
History of myocardial infarction or other systemic vasculopathies
Trial design
Treatments tested in this trial
- No intervention. This is an observational study.
Treatment groups
300 Participants
are divided into 3 treatment groupsSponsors and collaborators
Walter Reed National Military Medical Center
Lead sponsor
Johns Hopkins University
Collaborator
Source ClinicalTrials.gov