Cognitive Decline Following Deep Brain Stimulation
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMedical University of South Carolina
About this trial
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments.
Eligibility criteria
Qualifiers
Subjects above 18 years of age
Subjects who will undergo DBS surgery as part of their clinical care for PD
Disqualifiers
Uncorrected visual or hearing impairments, as indicated by self-report
Individuals who are pregnant or expect to become pregnant during the course of the study
Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
COPD with oxygen dependence
Trial design
Treatments tested in this trial
- Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care
Treatment groups
80 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov