Cognitive Impairment, Retinopathy, and Cerebrovascular Lesions in the Elderly
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age40+
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University
About this trial
The CIRCLE study is a single-center prospective observational study that enrolled individuals with cerebral small vessel disease (SVD), while free of known dementia or stroke (both cerebral infarction and hemorrhage). The patients will receive neuropsychological testing, retinal digital images and multimodal magnetic resonance imaging (MRI). Blood samples will also be collected. Recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy will be evaluated on both baseline and follow-up brain MRIs. The investigators will explore the predictors of preogression of SVD and cognitive deficits.
Eligibility criteria
Qualifiers
Adult (≥40y; no upper limit)
Free of known dementia or stroke (both cerebral infarction and hemorrhage)
Disqualifiers
Any MRI contraindications
Serious head injury (resulting to loss of consciousness) or received intracranial surgery
Suffering from cancer
Trial design
Treatments tested in this trial
- multimodal magnetic resonance imaging
Treatment groups
1,000 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov