Cognitive Rehabilitation Following Breast Cancer Treatment
ConditionBreast Cancer Female
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age20-75
SponsorUniversity of Missouri-Columbia
About this trial
The goal of this proposed project is to evaluate the feasibility and preliminary effect of metacognitive strategy training to improve activity performance, cognition, and quality of life in breast cancer survivors with cancer-related cognitive impairment (CRCI). The other goal of this proposed project is to examine the effects of CO-OP on resting (rsFC)- and task-state functional connectivity as compared to an inactive control group.
Eligibility criteria
Qualifiers
self-reported CRCI (Global Rating of Cognition dysfunction as "Moderately" "Strongly "or "Extremely" AND a Cognitive Failures Questionnaire1 (CFQ) score >30)
completed treatment for active cancer diagnosis (invasive ductal or lobular BrCA Stages I, II, or III) at least 6 months but not greater than 3 years prior to participation
able to read, write, and speak English fluently
able to provide valid informed consent
Disqualifiers
prior cancer diagnoses of other sites with evidence of active disease within the past year
active diagnoses of any acute or chronic brain-related neurological conditions that can alter normal brain anatomy or function (e.g., Parkinson's disease, dementia, cerebral infarcts) dementia symptoms as indicated by a score of <23 on the Montreal Cognitive Assessment (MoCA)
severe depressive symptoms (Personal Health Questionnaire-9 (PHQ-9) score of ≥21)
history of severe traumatic brain injury, prolonged loss of consciousness (e.g., coma)
Trial design
Treatments tested in this trial
- Metacognitive Strategy Training (MCST)
- Inactive Control Group
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Missouri-Columbia
Lead sponsor
National Institutes of Health (NIH)
Collaborator
National Cancer Institute (NCI)
Collaborator
Source ClinicalTrials.gov