Ulcerative colitis (UC) is a chronic disease characterized by acute episodes of bloody diarrhea with varying degrees of severity. The most feared event, acute severe UC, can lead to life-threatening and systemic complications. Little is known about the determinants of severity in UC. The investigators hypothesize that distinct severity phenotypes of UC arise from intricated host-microbiota mechanisms influencing repair mechanisms. Our first and main objective is to study the natural history of UC during a one-year time period in a cohort of patients.
Patients covered by a social security system.
French-speaking patients.
Patients aged ≥18 years.
Patients who have provided free, informed, and written consent (no later than the inclusion day and before any research-related examination).
Patients with perianal, ileal lesions, or endoscopic features of colonic lesions suggestive of Crohn's disease.
Pregnant or breastfeeding women.
Patients under legal protection or unable to provide informed consent.
Patients deprived of liberty by judicial or administrative decision, hospitalized without consent, or admitted to a healthcare or social institution for reasons unrelated to the study.