Cohort Study of PPP Injections for Athletes With Muscle Injury
ConditionLower Extremity Injury
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorUniversity of Colorado, Denver
About this trial
The investigators hypothesize that a single injection of platelet-poor plasma (PPP) into an acute muscle injury will significantly improve local muscle regeneration and patient outcomes compared to the standard of care using only ultrasound-guided hematoma aspiration. Muscle regeneration will be assessed through quantitative MRI analysis. The investigators anticipate that PPP injections will lead to a measurable reduction in scar tissue and an increase in regenerated muscle tissue at the injury site over a six-month period.
Eligibility criteria
Qualifiers
Age between 18 and 45 years
Diagnosis of a muscle strain in the lower extremities, including but not limited to hamstring, quadriceps, and gastrocnemius
Injury occurred within 10 days of the initial clinical evaluation
Injury occurred while engaging in athletic or sporting activities
Disqualifiers
Previous injection at the injury site.
Pregnant or breastfeeding women, or women who may become pregnant during the study duration
Injuries resulting from puncture or crush trauma
Injuries occurring more than 10 days prior to the injection date
Trial design
Treatments tested in this trial
- Platelet Poor Plasma (PPP) Injection
Treatment groups
90 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Colorado, Denver
Lead sponsor
Emory University
Collaborator
University of Iowa
Collaborator
Source ClinicalTrials.gov