Collecting Information About Treatment Results for Patients With Cushing's Syndrome
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age14+
SponsorMemorial Sloan Kettering Cancer Center
About this trial
The purpose of this study is to follow participants with Cushing's syndrome during the course of their routine care and to form a data registry to study long term participant outcomes.
Eligibility criteria
Qualifiers
Age 14 or older
Active or treated overt Cushing's (due to pituitary, ectopic, or adrenal tumor), mild adrenal Cushing's syndrome (MACS), or a silent corticotroph tumor
The diagnosis of CS or MACS will be made by the PI, based on the below Endocrine Society guidelines, the patient's clinical presentation, and the PI's judgment.
Diagnostic criteria for ACTH-dependent Cushing's are according to the Endocrine Society and European Society of Endocrinology guidelines and include: Elevated 24-hour urinary free cortisol (UFC), normal or elevated plasma ACTH, elevated midnight salivary cortisol levels, or classic dexamethasone suppression testing for CD (morning cortisol > 5 ug/dL after 1 mg overnight of classic 2-day low dose test) and a pituitary lesion on MRI (in the case of pituitary Cushing's). If patient does not have any of these results, pathology of ACTH tumor may confirm presence of disease.
Disqualifiers
Patients with a diagnosis of iatrogenic Cushing's.
Trial design
Treatments tested in this trial
- Cushing's QoL (Quality of Life Questionnaire)
- Nottingham Health Profile (NHP)
- Hospital Anxiety and Depression Scale (HADS)
- Perceived Stress Scale (PSS)
- Barratt's Impulsivity Scale (BIS)
- Beck Depression Inventory (BDI)
- State-Trait Anxiety Inventory (STAI)
- State Food Craving Questionnaire-State (FCQ-S)
- Trait Food Craving Questionnaire-Trait (FCQ-T)
- Visual Analogue Scale (VAS)
- Sensitivity to Reinforcement of Addictive and other Primary Rewards (STRAP-R) food variant
Treatment groups
300 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov