About this trial
CASCADE (Colorectal Analysis for Signature Cancer Assessment Using delta-HLD Technology) is a proof-of-concept case-control study designed to evaluate the performance of delta-HLD, Epiliquid's proprietary liquid biopsy technology, for the detection of colorectal cancer. Epiliquid also integrates a proprietary bioinformatic system capable of identifying, ranking, and selecting tumor-specific methylation biomarkers for different cancer types. In this study, colorectal cancer-specific biomarkers will be evaluated in blood and tissue samples using delta-HLD technology, which enables sensitive and multiplexed detection through PCR. Study results will support the validation of Epiliquid's integrated platform as a minimally invasive and accessible diagnostic solution for colorectal cancer.
Eligibility criteria
Qualifiers
Candidate for colonoscopy or colorectal surgery
Willing and able to provide informed consent
Able to provide blood and/or tissue sample before treatment or resection
Disqualifiers
Prior history of colorectal cancer
Inflammatory bowel disease
Known hereditary cancer syndromes (e.g., Lynch, FAP)
Other active malignancies
Trial design
Treatments tested in this trial
- Not listed