Colorectal Omics and OfCS Proteoglycans

ConditionsColorectal Cancer Diverticulitis, Colonic Inflammatory Bowel Diseases Stoma Colostomy

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorClaus Anders Bertelsen, PhD, MD

About this trial

This observational study aims to test proteomics, metabolomics and proteoglycans as predictors of postoperative complications after colorectal surgery and as biomarkers of colorectal cancer.

The main questions to answer are:

* can these biomarkers predict anastomotic leakages * can these biomarkers predict recurrence after colorectal cancer * can these biomarkers be used as diagnostic tests for colorectal cancer * can these biomarkers be identified in the tumor

Participants will undergo elective colorectal resection or stoma closure.

Eligibility criteria

Qualifiers

Patients diagnosed or with suspicion of colorectal cancer or adenoma, inflammatory bowel disease, late complications to colon diverticulosis, colostomy reversal or other diagnoses requiring colorectal resection.

Patients planned to undergo elective surgical procedures coded as KJFB20-KJFB99, KJFG30-37 or KJGB00-97 according to the Danish modification of the NOMESCO Classification of Surgical Procedures

Able to speak Danish, English, or other languages where professional interpretation is available

Able to give informed consent

Disqualifiers

Patients undergoing synchronous: liver resection (patients undergoing metastasectomies can be included); total gastrectomy or cardia resection; Whipple's procedure or another major pancreatic resection (resections of the pancreatic tail can be included); total or partial nephrectomies or cystectomy

Patients previously included in the study

Patients known to be pregnant (pregnancy test not required)

Non-resident in Denmark

Trial design

Treatments tested in this trial

Colorectal resection or stoma closure

Treatment groups

1,000 Participants

are divided into 1 treatment group

Sponsors and collaborators

Claus Anders Bertelsen, PhD, MD

Lead sponsor

Nordsjaellands Hospital

Sponsor institution

Viborg Regional Hospital

Collaborator

Source ClinicalTrials.gov