Colorimetric, Ultra-structural and Elemental Comparison of Dental Enamel Defects
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age8-55
SponsorAssistance Publique - Hôpitaux de Paris
About this trial
The study focuses on the analysis of enamel defects grouping together hypomineralization and hypoplasia. It focuses on 3 very characteristic enamel pathologies that are most often encountered in dental consultations: Molar Incisor Hypomineralization (MIH), dental fluorosis (FD) and amelogenesis imperfecta (AI). The research focuses on the use of a spectrophotometer for measuring tooth colors: the Zfx SpectroShade® (MHT) and its software as a means of early diagnosis of pre-eruptive enamel abnormalities. The main objective of the study is to analyze the color parameters of teeth affected with one of the 3 enamel abnormalities for use of the spectrophotometer as a non-invasive diagnostic tool for enamel defects.
The secondary objective is focused on the biological, structural and physicochemical characterizations of these different enamel pathologies from extracted teeth or enamel biopsies that must be ground to achieve a restoration.
Eligibility criteria
Qualifiers
Age between 8 and 55 years old
Carrier of one of the following 3 quantitative pre-eruptive enamel anomalies : AIH, dental fluorosis or MIH
Information and collection of the non-opposition of the adult patient or of the representative(s) of parental authority present for the minors.
Pregnant or breastfeeding woman
Disqualifiers
None
Trial design
Treatments tested in this trial
- spectrophotometer
- Biological (protein analysis by western blot or mass spectrometry of matrix proteins), structural (electron microscopy) and physico-chemical analyses
Treatment groups
80 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov