Combined Use of Bacteroides Fragilis and BCAAs on HBsAg Clearance

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFirst Affiliated Hospital of Fujian Medical University

About this trial

The goal of this prospective observational study is to determine the effects of concomitant administration of Bacteroides fragilis and Branched-Chain Amino Acids on hepatitis B virus clearance. The primary question it aims to answer is whether this concomitant administration can promote HBV clearance.

The study will observe the HBV clearance rate in chronic hepatitis B patients who receive Bacteroides fragilis and BCAA as a supplement to their routine antiviral therapy. For comparison, researchers will compare the clearance rate in this group to that observed in a control group of chronic hepatitis B patients receiving a standard antiviral regimen based on PegIFNα2b and nucleoside analogs.

Eligibility criteria

Qualifiers

None

Disqualifiers

patients with malignancies

patients with other liver diseases

pregnancy patients

Trial design

Treatments tested in this trial

  • PegIFNα2b+Nucleoside analog
  • PegIFNα2b+Nucleoside analog+Bacteroides fragilis+Branched-Chain Amino Acids

Treatment groups

40 Participants
are divided into 2 treatment groups