"PRP+HA-23" is a double-blind randomized controlled clinical trial with 1:1:1 allocation. The objective of the study is to evaluate by a randomized controlled, double-blind clinical trial the efficacy and safety of viscosupplementation-associated PRP infiltration compared with PRP-only or HA-only infiltration for the treatment of patients with knee osteoarthritis.
Male or female patients, aged 40 to 75 years;
Patients with symptomatic knee osteoarthritis (VAS pain score between ≥ 3 and ≤ 8);
Unilateral involvement of symptomatology;
Radiographic or MRI signs of degenerative pathology of knee cartilage (Kellgren-Lawrence grade 1-3);
Patients unable to express consent;
Patients undergoing intra-articular infiltration of other substance in the previous 6 months;
Patients undergoing knee surgery in the previous 12 months;
Patients with malignant neoplasms;
Istituto Ortopedico Rizzoli
Lead sponsor
University Hospital of Ferrara
Collaborator