About this trial
To compare the efficacy of lesional high-frequency rTMS, contralesional cTBS, and sham stimulation in improving motor and cognitive recovery in post-stroke patients undergoing physiotherapy.
Eligibility criteria
Qualifiers
First-ever ischemic stroke, confirmed by imaging.
Stroke affecting the non-dominant hemisphere (cortical or subcortical) within the middle cerebral artery (MCA) territory.
Acute to subacute stage of stroke (time since onset: 48 hours to 2 weeks).
Ability to comply with the study protocol and interventions.
Disqualifiers
Hemorrhagic stroke or bilateral stroke.
Severe cognitive impairment, defined as a Montreal Cognitive Assessment (MoCA) score < 10.
Contraindications to TMS, such as: History of epilepsy, Metallic implants in the head, Other contraindications based on TMS safety guidelines.
Comorbid conditions that limit participation in rehabilitation.
Trial design
Treatments tested in this trial
- Ipsilesional high frequency rTMS combined with physiotherapy
- Contralesional Continuous Burst Theta rTMS (cTBS) + Physiotherapy
- Sham rTMS + Physiotherapy