Comparative Effectiveness of Ipsilesional High-frequency rTMS, Contralesional Continuous Burst Theta rTMS, and Sham rTMS, Each Combined With Physiotherapy, in Subacute Ischemic Stroke Upper Limb Recovery : Clinical, Neurophysiological and Radiological

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-70
SponsorAssiut University

About this trial

To compare the efficacy of lesional high-frequency rTMS, contralesional cTBS, and sham stimulation in improving motor and cognitive recovery in post-stroke patients undergoing physiotherapy.

Eligibility criteria

Qualifiers

First-ever ischemic stroke, confirmed by imaging.

Stroke affecting the non-dominant hemisphere (cortical or subcortical) within the middle cerebral artery (MCA) territory.

Acute to subacute stage of stroke (time since onset: 48 hours to 2 weeks).

Ability to comply with the study protocol and interventions.

Disqualifiers

Hemorrhagic stroke or bilateral stroke.

Severe cognitive impairment, defined as a Montreal Cognitive Assessment (MoCA) score < 10.

Contraindications to TMS, such as: History of epilepsy, Metallic implants in the head, Other contraindications based on TMS safety guidelines.

Comorbid conditions that limit participation in rehabilitation.

Trial design

Treatments tested in this trial

  • Ipsilesional high frequency rTMS combined with physiotherapy
  • Contralesional Continuous Burst Theta rTMS (cTBS) + Physiotherapy
  • Sham rTMS + Physiotherapy

Treatment groups

90 Participants
are divided into 3 treatment groups

Locations

This trial has no locations

Sponsors and collaborators