This clinical trial aims to compare the efficacy and safety of acetazolamide versus metolazone as adjunctive treatments to standard therapy in patients with acute decompensated heart failure (ADHF). ADHF is a life-threatening condition, and current treatments often involve loop diuretics to alleviate volume overload. This study will assess the added benefit of acetazolamide and metolazone in improving decongestion, reducing hospital stays, and preventing complications such as renal dysfunction or electrolyte imbalances. Participants will be randomized to receive either acetazolamide or metolazone in addition to standard diuretic therapy. The trial will evaluate primary outcomes including successful decongestion, in-hospital mortality, and length of hospital stay, with secondary outcomes focusing on renal function, electrolyte disturbances, and overall safety. The study is conducted at Bahawal Victoria Hospital, Bahawalpur, and aims to provide valuable insights into the management of ADHF, especially in the Pakistani population.
Aged 18 years or older.
Diagnosed with Acute Decompensated Heart Failure (ADHF), with either preserved or reduced ejection fraction (EF).
Pleural effusion (confirmed by chest X-ray or ultrasound).
Oedema or ascites (verified by abdominal ultrasonography).
Previous use of acetazolamide or metolazone prior to the study period.
Known hypersensitivity or allergies to the study drugs (acetazolamide or metolazone) or their components.
Patients with electrolyte disturbances, especially hypokalemia.
End-stage renal disease requiring dialysis or GFR < 20 mL/min/1.73 m².