This study aims to compare the efficacy of different doses of glucocorticoids in local infiltration analgesia (LIA) during total knee arthroplasty (TKA) through a prospective single-center randomized controlled trial, and to explore the safety and feasibility of high-dose glucocorticoids. Through this research, the investigators hope to provide an optimized solution for post-TKA pain management, improve patients' postoperative recovery and quality of life, and offer scientific evidence for pain management following TKA.
Male or female participants aged 18 years or older;
Undergoing primary unilateral total knee arthroplasty (TKA)for unilateral knee osteoarthritis(OA)at ourhospital;
Preoperative American Society of Anesthesiologists(ASA)physical status classification of 1-3;
Ability to provide informed consent and sign a written informed consent form.
Previous surgery on the operative knee or a history of infection in the operative knee;
Non-osteoarthritis conditions (including rheumatoid arthritis, traumatic arthritis, septic arthritis, and hemophilic arthritis);
Severe osteoarthritis (including flexion contracture >30° or varus/valgus deformity >30°);
Allergy to the relevant study drugs;