About this trial
Single blinded randomized controlled study of symptom improvement after uterine artery embolization (UAE) versus ultrasound guided percutaneous/transvaginal microwave ablation, evaluated by validated questionnaires.
Adenomyosis is a benign condition causing pain and bleeding disorders in many women. Hysterectomy has historically been the golden standard for treatment as well as (postoperatively) diagnosis of the disease. In accordance with refined diagnostic tools such as ultrasound and/or MRI, minimally invasive treatments for adenomyosis are being explored.
We plan to compare two minimally invasive techniques: embolization of the uterine artery (a commonly used procedure) and microwave ablation of adenomyotic tissue (previously only in clinical use in China).
Eligibility criteria
Qualifiers
Healthy women aged 30-55 with symptomatic adenomyosis
Premenopausal
Adenomyosis diagnosted by TVUS
Willing to comply with protocol
Disqualifiers
Body Mass Index >35
Treatment with anticoagulant/bleeding disorder
Contraindication for UAE or general anesthesia
Trial design
Treatments tested in this trial
- Microwave treatment via needle antenna
- Embolization of uterine artery or branches thereof (routine treatment where polyvinyl alcohol particles are released into the predefined bloodstream)