Comparing Efficacy of Microwave Vs Embolization Treatment for Adenomyosis

ConditionAdenomyosis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age30-55
SponsorKarolinska Institutet

About this trial

Single blinded randomized controlled study of symptom improvement after uterine artery embolization (UAE) versus ultrasound guided percutaneous/transvaginal microwave ablation, evaluated by validated questionnaires.

Adenomyosis is a benign condition causing pain and bleeding disorders in many women. Hysterectomy has historically been the golden standard for treatment as well as (postoperatively) diagnosis of the disease. In accordance with refined diagnostic tools such as ultrasound and/or MRI, minimally invasive treatments for adenomyosis are being explored.

We plan to compare two minimally invasive techniques: embolization of the uterine artery (a commonly used procedure) and microwave ablation of adenomyotic tissue (previously only in clinical use in China).

Eligibility criteria

Qualifiers

Healthy women aged 30-55 with symptomatic adenomyosis

Premenopausal

Adenomyosis diagnosted by TVUS

Willing to comply with protocol

Disqualifiers

Body Mass Index >35

Treatment with anticoagulant/bleeding disorder

Contraindication for UAE or general anesthesia

Trial design

Treatments tested in this trial

  • Microwave treatment via needle antenna
  • Embolization of uterine artery or branches thereof (routine treatment where polyvinyl alcohol particles are released into the predefined bloodstream)

Treatment groups

70 Participants
are divided into 2 treatment groups

Sponsors and collaborators