About this trial
Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic surgeries to be performed safely. Hypothermic circulatory arrest provides protection to cerebral and visceral organs, but may result in longer cardiopulmonary bypass times during surgery, increased risks of bleeding, inflammation, and neuronal injury. To manage these consequences, a trend towards warmer core body temperatures during circulatory arrest has emerged. This trial will randomize patients to either mild (32°C) or moderate (26°C) hypothermia during aortic hemiarch surgery to determine if mild hypothermia reduces the length of cardiopulmonary bypass time and other key measures of morbidity and mortality.
Eligibility criteria
Qualifiers
Age ≥ 18 years
Elective aortic hemiarch surgery
Planned unilateral selective anterograde cardioplegia
Anticipated lower body arrest time of < 20 minutes
Disqualifiers
Surgery for acute aortic dissection or emergent operations
Total arch replacement
Inability to perform unilateral selective anterograde cerebral perfusion (uSACP)
Patients with known/documented coagulopathy
Trial design
Treatments tested in this trial
- Hypothermic circulatory arrest