Comparing Hypothermic Temperatures During Hemiarch Surgery

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorOttawa Heart Institute Research Corporation

About this trial

Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic surgeries to be performed safely. Hypothermic circulatory arrest provides protection to cerebral and visceral organs, but may result in longer cardiopulmonary bypass times during surgery, increased risks of bleeding, inflammation, and neuronal injury. To manage these consequences, a trend towards warmer core body temperatures during circulatory arrest has emerged. This trial will randomize patients to either mild (32°C) or moderate (26°C) hypothermia during aortic hemiarch surgery to determine if mild hypothermia reduces the length of cardiopulmonary bypass time and other key measures of morbidity and mortality.

Eligibility criteria

Qualifiers

Age ≥ 18 years

Elective aortic hemiarch surgery

Planned unilateral selective anterograde cardioplegia

Anticipated lower body arrest time of < 20 minutes

Disqualifiers

Surgery for acute aortic dissection or emergent operations

Total arch replacement

Inability to perform unilateral selective anterograde cerebral perfusion (uSACP)

Patients with known/documented coagulopathy

Trial design

Treatments tested in this trial

  • Hypothermic circulatory arrest

Treatment groups

282 Participants
are divided into 2 treatment groups