COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-40
SponsorDow University of Health Sciences

About this trial

The goal of this clinical trial is to learn if norepinephrine is more effective than phenylephrine for prevention of spinal anesthesia induced hypotension. The main questions it aims to answer are:

Does norepinephrine lower the incidence of spinal anesthesia induced hypotension in emergency obstetrical patients? We will compare effectiveness of norepinephrine and phenylephrine for the prevention of spinal anesthesia induced hypotension.

Participants will:

Be administered prophylactic boluses of both drugs right after spinal anesthesia induction and maternal hemodynamic parameters and neonatal APGAR scores will be recorded

Eligibility criteria

Qualifiers

American society of anesthesiologists II and III patients

Age 18-40years

Gestational age 32 weeks and above

Disqualifiers

Patients with hypertensive disorders of pregnancy having baseline systolic blood pressure greater than 160 mmHg and diastolic blood pressure greater than 99 mmHg.

Baseline mean arterial pressure less than 70 mmHg.

Antepartum hemorrhage/intraoperative blood loss greater than 1000ml

history indicative of cardiovascular or neurological disease.

Trial design

Treatments tested in this trial

  • Norepinephrine Bolus
  • Phenylephrine bolus

Treatment groups

124 Participants
are divided into 2 treatment groups