Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorHarran University
About this trial
This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Prone positioning may adversely affect lung compliance and gas exchange, making optimal ventilatory strategies essential. Driving pressure and mechanical power are considered key determinants of ventilator-induced lung stress. This study will evaluate the impact of different PEEP levels on respiratory parameters and intraoperative physiological changes.
Eligibility criteria
Qualifiers
Patients aged between 18 and 65 years
American Society of Anesthesiologists (ASA) physical status I-II
Scheduled for elective lumbar spine surgery in the prone position
Planned general anesthesia with total intravenous anesthesia (TIVA)
Disqualifiers
Body mass index (BMI) ≥ 30 kg/m²
History of significant pulmonary disease (e.g., COPD, asthma)
Severe cardiovascular disease
Pregnancy
Trial design
Treatments tested in this trial
- Mechanical Ventilation (PEEP)
Treatment groups
60 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov