Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-40
SponsorHanoi General Hospital (Vietnam)
About this trial
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
Eligibility criteria
Qualifiers
Women aged 18-40 years
Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound)
Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI)
Eligible for controlled ovarian stimulation for IVF
Disqualifiers
Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology.
History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy)
History of recurrent pregnancy loss (≥3 spontaneous miscarriages)
Known chromosomal abnormalities in either partner
Trial design
Treatments tested in this trial
- Progestin-Primed Ovarian Stimulation (PPOS)
- GnRH Antagonist Protocol
Treatment groups
400 Participants
are divided into 2 treatment groupsSponsors and collaborators
Hanoi General Hospital (Vietnam)
Lead sponsor
Hanoi Medical University
Sponsor institution
Source ClinicalTrials.gov