Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer

ConditionsColorectal Cancer Metastatic Brain Metastases, Adult Ras (KRAS or NRAS) Gene Mutation BRAF Gene Mutation HER2 Gene Mutation MSI

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorBlokhin's Russian Cancer Research Center

About this trial

GENCONCOR-1 study is translational research aimed to investigate the concordance of the molecular genetic profile of the primary tumor and brain metastases (BM) of colorectal cancer (CRC). The study was conducted by post hoc analysis of pairs of samples of histological material with determination of the mutational status of genes KRAS, NRAS, BRAF, HER2 and MSI.

Eligibility criteria

Qualifiers

Men and women over 18 years of age.

Histologically confirmed cancer of the colon or rectum.

Histologically confirmed metastatic lesion of the brain.

Neurosurgical resection for brain metastases of colorectal cancer.

Disqualifiers

Missing one sample from a pair of tumor samples.

Low quality or lack of tumor material for molecular genetic research.

Trial design

Treatments tested in this trial

Tumor samples will be tested for mutation status of KRAS, NRAS, BRAF, HER2 and MSI

Treatment groups

No treatment groups listed

Sponsors and collaborators

Blokhin's Russian Cancer Research Center

Lead sponsor

Source ClinicalTrials.gov