Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorJian-Xin Zhou

About this trial

Spontaneous breathing trials (SBT) are essential for assessing extubation tolerance, yet optimal approaches are debated. High-flow nasal oxygen offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function. While high-flow tracheal oxygen can also be used as an SBT method, it has reduced physiological effects due to bypassing the upper airway with a more open circuit. To enhance this limitation, investigators developed a modified high-flow tracheal oxygen tube with a smaller expiratory end diameter to increase expiratory resistance and airway pressure. This is a prospective randomized crossover study that aims to compare the physiological effects of standard and modified high-flow tracheal oxygen versus T-piece during SBT.

Eligibility criteria

Qualifiers

Mechanical ventilation for more than 24 hours

Considered by the physicians for the readiness to wean and ready for spontaneous breathing trials

Disqualifiers

Age younger than 18 years old

Pregnancy

Hemodynamic instability (mean arterial pressure <60 mmHg, heart rate >140 or <60 bpm)

Respiratory and oxygenation instability (respiratory rate > 35bpm or oxygen saturation measured by pulse oximetry <90%)

Trial design

Treatments tested in this trial

  • Modified high flow tracheal oxygen-40L/min
  • Standard high flow tracheal oxygen-40L/min
  • T-piece
  • Modified high-flow tracheal oxygen-60L/min
  • Standard high-flow tracheal oxygen-60 L/min

Treatment groups

20 Participants
are divided into 5 treatment groups

Sponsors and collaborators

Jian-Xin Zhou

Lead sponsor

Capital Medical University

Sponsor institution