Comparison of Physiological Effects of Two Types of High-Flow Oxygen Therapy in Tracheostomized Patients

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorJian-Xin Zhou

About this trial

High-flow nasal oxygen therapy offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function. High-flow oxygen therapy can be applied via tracheostomy as high-flow tracheal oxygen. While high-flow tracheal oxygen has been used to facilitate weaning, it has diminished physiological effects due to bypassing upper airways. To enhance its effectiveness, researchers developed a modified high-flow tracheal oxygen tube with a smaller expiratory end diameter to increase airway resistance and pressure. This is a prospective randomized crossover study that aims to compare the physiological effects of standard and modified high-flow oxygen therapy in tracheostomized patients.

Eligibility criteria

Qualifiers

None

Disqualifiers

Age younger than 18 years old

Pregnancy

Hemodynamic instability (mean arterial pressure <60 mmHg, heart rate >140 or <60 bpm)

Respiratory and oxygenation instability (respiratory rate > 35bpm or oxygen saturation measured by pulse oximetry <90%)

Trial design

Treatments tested in this trial

  • Modified high flow tracheal oxygen
  • Standard high flow tracheal oxygen

Treatment groups

20 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Jian-Xin Zhou

Lead sponsor

Capital Medical University

Sponsor institution