About this trial
High-flow nasal oxygen therapy offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function. High-flow oxygen therapy can be applied via tracheostomy as high-flow tracheal oxygen. While high-flow tracheal oxygen has been used to facilitate weaning, it has diminished physiological effects due to bypassing upper airways. To enhance its effectiveness, researchers developed a modified high-flow tracheal oxygen tube with a smaller expiratory end diameter to increase airway resistance and pressure. This is a prospective randomized crossover study that aims to compare the physiological effects of standard and modified high-flow oxygen therapy in tracheostomized patients.
Eligibility criteria
Qualifiers
None
Disqualifiers
Age younger than 18 years old
Pregnancy
Hemodynamic instability (mean arterial pressure <60 mmHg, heart rate >140 or <60 bpm)
Respiratory and oxygenation instability (respiratory rate > 35bpm or oxygen saturation measured by pulse oximetry <90%)
Trial design
Treatments tested in this trial
- Modified high flow tracheal oxygen
- Standard high flow tracheal oxygen
Treatment groups
Sponsors and collaborators
Jian-Xin Zhou
Lead sponsor
Capital Medical University
Sponsor institution