Comparison of Proton and Photon Radiotherapy of Brain Tumors (ProtoChoice-Hirn)
ConditionBrain Tumors
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorTechnische Universität Dresden
About this trial
This protocol compares the toxicity of radiotherapy or radiochemotherapy applied with different radiation modalities - protons or photons. Patients with different kinds of brain tumours and foreseen high-dose radiotherapy can be included. The hypothesis of the trial is that the rate of chronic toxicity 1 year after the end of radiotherapy is 15% lower after proton compared to photon treatment.
Eligibility criteria
Qualifiers
primary brain tumor: gliomas (low or high grade), intracerebral meningiomas, pituitary adenomas, craniopharyngioma and other rare brain tumors or
brain tumor recurrence without pre-irradiation or
brain tumor recurrence with pre-irradiation > 40 Gy in the overlap region with the recurrence region
indication for radiotherapy or radiochemotherapy
Disqualifiers
lack of capacity to consent or lack of written consent
cerebral lymphomas
brain metastases
very small tumors (for example acoustic neuromas, very small recurrences) for this is a proton therapy from a medical point of view no alternative to a stereotactic radiotherapy
Trial design
Treatments tested in this trial
- Radiation with protons
- Radiation with photons
Treatment groups
555 Participants
are divided into 8 treatment groups8
Treatment groupsSee each treatment group below.
Sponsors and collaborators
Technische Universität Dresden
Lead sponsor
German Cancer Research Center
Collaborator
National Center for Radiation Research in Oncology Dresden/Heidelberg
Collaborator
Source ClinicalTrials.gov