Health TrialsbyHealthPanel

Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors

ConditionsLiver TransplantationPain Management
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorAnkara Etlik City Hospital

About this trial

Liver transplantation is a life-saving procedure for patients with end-stage liver disease, and postoperative pain management is critical for optimizing donor recovery and overall outcomes. Poorly controlled pain following donor hepatectomy may reduce quality of life, delay mobilization, and contribute to the development of chronic pain syndromes.

Regional anesthesia techniques, such as intrathecal morphine and erector spinae plane block, have been utilized to enhance postoperative analgesia and reduce perioperative opioid requirements, potentially minimizing opioid-related adverse effects.

In this study, we aimed to compare the postoperative analgesic efficacy of intrathecal morphine and Bi-level erector spinae plane block in living liver donors.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients aged 18-65 years

American Society of Anesthesiologists (ASA) score I-II

Body Mass Index (BMI) between 18-30 kg/m2

Disqualifiers

Patients under 18 and over 65 years of age

ASA score III and above

Patients with a history of bleeding diathesis

BMI below 18 or above 30 kg/m2

Trial design

Design model

Parallel

Treatments tested in this trial

  • Intrathecal Morphine

    Procedure/Surgery

    An intrathecal injection of morphine 300μg will be administered at the L3-L4 or L4-L5 level. Additionally, in the postoperative period a dexketoprofen dose of 50 mg twice daily were administered iv for multimodal analgesia.

  • Bi-level Erector Spinae Plane Block

    Procedure/Surgery

    Bi-level erector spinae plane block will be performed on the patients using a total of 40 ml of 0.25% bupivacaine under ultrasound guidance. Additionally, in the postoperative period a dexketoprofen dose of 50 mg twice daily were administered iv for multimodal analgesia.

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Intrathecal MorphineActive comparator 1 intervention
Group B: Bi-level Erector Spinae Plane BlockActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Pain Scores

Pain will be assessed at rest and while coughing using the visual analog scale on a scale from 0 (no pain) to 10 (worst pain). Pain assessment will be done at 0st, 1st, 2nd,4th, 12th, and 24th hours after surgery.

Time frame
On the operation day

Secondary outcomes

1

Intraoperative opioid consumption

Remifentanil consumption for intraoperative period will be recorded

Time frame
Intraoperative period
2

Postoperative Opioid Consumption

Opioid consumption for 24 hours will be recorded

Time frame
On the operation day

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ankara Etlik City Hospital

Lead sponsor

Source ClinicalTrials.gov
Apply now