Comparison of Two Qualia NAD⁺ Formulations on Intracellular NAD⁺ Levels

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age35-75
SponsorQualia Life Sciences

About this trial

This is a randomized, double-blind, placebo-controlled, parallel-group study evaluating the effects of two distinct Qualia NAD⁺ formulations on intracellular NAD⁺ levels in healthy adults aged 35-75 years. Approximately 180 participants will be randomized to one of three study arms: Qualia NAD⁺ version 1, Qualia NAD⁺ version 2, or placebo. Each participant will take two capsules of their assigned product once daily in the morning, with or without food, over a 28-day period. The primary outcome is the change in intracellular NAD⁺ levels, assessed via at-home finger-stick blood collection at baseline and study completion. Secondary endpoints include changes in aging-related symptoms (AMFS scores), health-related quality of life (RAND SF-36), and evaluation of safety and tolerability. All assessments, including electronic questionnaires, are completed remotely without in-person visits.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Qualia NAD⁺ version 1

    Dietary supplement

    Qualia NAD+ version 1 manufactured by Qualia Life Sciences

  • Qualia NAD⁺ version 2

    Dietary supplement

    Qualia NAD+ version 2 manufactured by Qualia Life Sciences

  • Placebo

    Dietary supplement

    Rice Flour

Treatment groups

180 Participants
are divided into 3 treatment groups
Group A: Qualia NAD⁺ version 1Active comparator 1 intervention
Group B: Qualia NAD⁺ version 2Active comparator 1 intervention
Group C: PlaceboPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Between-group change in intracellular NAD⁺ levels

To assess between-group differences in the change in intracellular NAD⁺ levels from baseline to Week 4 following supplementation with Qualia NAD version 1, Qualia NAD version 2, or placebo.

Time frame
28 days

Secondary outcomes

1

Aging-Related Symptoms (AMFS scores)

To evaluate within-group and between-group differences in the change in Aging Male/Female Symptom (AMFS) total and sub-scale scores.

Time frame
4 weeks
2

RAND SF-36 Scale Scores

To assess within-group and between-group differences in RAND SF-36 domain scores.

Time frame
4 weeks
3

Side effect profile as measured by a custom Safety and Tolerability survey

To evaluate side effect profiles using a custom Safety and Tolerability survey.

Time frame
Week 1, 2, 3, and 4
4

Within-group differences in the change in intracellular NAD⁺ levels

To assess within-group differences in the change in intracellular NAD⁺ levels

Time frame
4 weeks

Other outcomes

Sponsors and contacts

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