Comperative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation in Subacute Stroke Patients

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45-70
SponsorLahore University of Biological and Applied Sciences

About this trial

This study aims to determine whether transcutaneous vagus nerve stimulation (tVNS) via auricular or cervical branches enhances recovery when combined with task-specific training in subacute stroke patients. We anticipate finding that both stimulation methods may improve upper limb motor function compared to conventional therapy. The research is expected to reveal specific cognitive domains (attention, memory, executive function) that benefit most from each stimulation approach, while also demonstrating meaningful improvements in patients' quality of life measures. These findings may make a significant practical contribution by providing clinicians with evidence-based guidance on suitable tVNS approach for improving functional independence and quality of life for stroke survivors.

Eligibility criteria

Qualifiers

First ever ischemic stroke

Subacute phase of stroke 3-6 months post onset

Fugl-Meyer Assessment-Upper Extremity (FMA-UE) scores ranged from 20 - 50

Disqualifiers

Previous injury or surgical intervention of vagus nerve

Patients with cardiac arrest and arrythmias

Uncontrolled hypertension

Apraxia

Trial design

Treatments tested in this trial

  • Transcutaneous vagus nerve stimulation through auricular branch along with task specific exercises
  • Transcutaneous vagus nerve stimulation through cervical branch along with task specific exercises

Treatment groups

54 Participants
are divided into 2 treatment groups