COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age8-18
SponsorAmerican University of Beirut Medical Center
About this trial
The goal of this observational study is to investigate whether the A118G single-nucleotide polymorphism (SNP) in the mu-opioid receptor1(OPRM1) and Catechol-O-methyltransferase (COMT) SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries.
The main question\[s\] it aims to answer \[is\]:
Do OPRM1 and COMT SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries?
Participants will be assessed for their pain scores, sedation level, the amount of postoperative analgesics received, duration of their stay in the post-anesthesia care unit, and toxicity.
Eligibility criteria
Qualifiers
All children 8 years to 18 years
Undergoing orthopedic, abdominal, thoracic, and plastic surgeries
American Society of Anesthesiologists classification (ASA) I-II-III
Disqualifiers
Children with schizoid personality disorders, phobias, and anxiety
Patients with neuropathic pain associated with surgeries requiring surgical treatment.
Children presented with all types of depressive disorders, atypical bipolar disorder, or a suspicion of substance abuse.
American Society of Anesthesiologists classification (ASA) ≥IV
Trial design
Treatments tested in this trial
- Not listed
Trial groups
No trial groups listed
Sponsors and collaborators
Source ClinicalTrials.gov