Objective of the study is to determine whether combined use of intraoperative fluorescence with 5-aminolevulinic acid (5-ALA) and sonography can achieve higher rate of gross total resection of contrast-enhancing gliomas and brain metastases compared to intraoperative fluorescence with 5-ALA alone.
single gliomas with contrast enhancement in preoperative magnetic resonance imaging (presumed high-grade gliomas)
one or several brain metastases from any cancer
newly diagnosed
Karnofsky Performance Status 60-100%
tumor spreading to corpus callosum or brainstem
previously performed brain radiotherapy
planned supratotal tumor resection until neurophysiologically revealed eloquent areas
known hypersensibility to 5-aminolevulinic or to porphyrin