Concurrent TMS-fMRI
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorJing Jiang
About this trial
The goal of this clinical trial is to examine the neural mechanisms underlying transcranial magnetic stimulation (TMS) using concurrent functional magnetic resonance imaging (fMRI) in both healthy controls (HCs) and patients with high negative affect symptoms, such as depression. Approximately half male and half female participants aged 18-65 will be recruited.
The main questions it aims to answer are:
1. Is the acute/transient effect induced by single-pulse TMS related to the long-term modulatory effect induced by repetitive TMS (rTMS)? 2. Do any of these effects predict negative affect symptoms, such as depression?
Participants will:
1. Complete several tests to assess their cognitive abilities and emotional states 2. Undergo several brain scans, including resting-state fMRI, structural MRI, diffusion tensor imaging (DTI), and task fMRI 3. Have two different types of TMS sequences, single-pulse and repetitive pulses, administered to specific brain regions while undergoing fMRI
Eligibility criteria
Qualifiers
Diagnosis of major depressive disorder
Age greater than or equal to 18 years
Age less than or equal to 65 years
Able to understand and consent for research participation
Disqualifiers
Implanted device including pacemaker, coronary stent, defibrillator, or neurostimulation device that is not MRI-compatible
Metal in body including bullets, shrapnel, metal slivers
Claustrophobia
Uncontrolled high blood pressure
Trial design
Treatments tested in this trial
- spTMS-TBS-spTMS
Treatment groups
97 Participants
are divided into 1 treatment groupSponsors and collaborators
Jing Jiang
Lead sponsor
University of Iowa
Sponsor institution
National Institutes of Health (NIH)
Collaborator
National Institute of Mental Health (NIMH)
Collaborator
Source ClinicalTrials.gov