Contribution of Transthoracic and Transcranial Ultrasonography to the Titration of PEEP in Patients With ARDS and ABI
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorTheodoros Schizodimos
About this trial
The present study will investigate whether the combined use of lung and brain ultrasonography is useful in selecting the optimal positive end-expiratory pressure in mechanically ventilated critically ill patients with acute respiratory distress syndrome and acute brain injury, aiming at an individualized, brain-protective ventilation strategy.
Eligibility criteria
Qualifiers
Age ≥ 18 years
Severe acute brain injury (e.g., traumatic brain injury, subarachnoid hemorrhage, intracerebral hemorrhage, acute ischemic stroke)
Development of ARDS (according to Berlin criteria) within the first 10 days of ICU admission
Disqualifiers
Severe chronic brain diseases
Brain tumor or central nervous system (CNS) infection
Severe chronic pulmonary or cardiovascular disease
Severe coagulopathy
Trial design
Treatments tested in this trial
- Stepwise Positive End-Expiratory Pressure (PEEP) Increase Protocol
Treatment groups
30 Participants
are divided into 1 treatment groupSponsors and collaborators
Theodoros Schizodimos
Lead sponsor
George Papanicolaou Hospital
Sponsor institution
Source ClinicalTrials.gov