Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

ConditionsMild Traumatic Brain Injury Moderate Traumatic Brain Injury Mild Cognitive Impairment

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age30-90

SponsorVA Office of Research and Development

About this trial

This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after brain injury and in dementia.

Eligibility criteria

Qualifiers

Intact color vision

Visual acuity of 20/30 (or better)

Patients must pass effort measures on the TOMM

Patients must have intact decision-making capacity

Disqualifiers

If the primary language is not English

Are unable to understand the informed consent process

A history of TBI within 1 year of study

Suicidal or homicidal ideation requiring intervention

Trial design

Treatments tested in this trial

No Intervention is used for this study but all subjects will be asked to complete EEG testing and an MRI scan.
No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure.

Treatment groups

800 Participants

are divided into 6 treatment groups

Treatment groups

See each treatment group below.

Sponsors and collaborators

VA Office of Research and Development

Lead sponsor

VA Boston Healthcare System

Collaborator

Source ClinicalTrials.gov