CORE-COMPARE Pilot Study
ConditionCoronary Heart Disease (CHD)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-85
SponsorJohns Hopkins University
About this trial
The utility of Ultra High-Resolution Computed Tomography (UHR-CT) compared to conventional CT in all-comers (i.e., a generally lower-risk population) remains uncertain but is an important area of study in order to justify wider spread implementation and use of this technology, particularly in light of reports of significantly higher radiation exposure with UHR-CT, as well as longer scan times. The availability of technology to reconstruct conventional resolution (CR) simulation images from the raw CT acquisition data acquired on the UHR-CT scanner offers a unique platform to study this question without subjecting individuals to two different scans.
The primary objective of this study is to generate preliminary data in support of the hypothesis that noninvasive UHR-CT is superior to conventional resolution CT for identifying patients with obstructive CHD.
Eligibility criteria
Qualifiers
Patients aged 21-85 years
Clinical history suggestive of CHD who are referred by their primary cardiologist for further evaluation via Computed tomography angiography (CTA) will be asked to participate.
Women of child bearing potential must demonstrate a negative pregnancy test within 24 hours of the study CTA.
Ability to understand and willingness to sign the Informed Consent Form.
Disqualifiers
Known allergy to iodinated contrast media.
History of multiple myeloma or previous organ transplantation
Elevated serum creatinine (> 1.5mg/dl) OR calculated creatinine clearance of < 60 ml/min (using the Cockcroft-Gault formula
Atrial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block (second or third degree heart block)
Trial design
Treatments tested in this trial
- Aquilion Precision
- Conventional Computed Tomography
Treatment groups
140 Participants
are divided into 2 treatment groupsSponsors and collaborators
Johns Hopkins University
Lead sponsor
Canon Medical Systems, USA
Collaborator
Source ClinicalTrials.gov