Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal Melting

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorCentre hospitalier de l'Université de Montréal (CHUM)

About this trial

The purpose of this study is to demonstrate the safety and efficacy of the corneal collagen crosslinking with riboflavin and ultraviolet A in aim to increase the resistance of the graft used as a support for the Boston keratoprosthesis (KPro) type I against corneal melting (keratolysis or sterile necrosis).

Eligibility criteria

Qualifiers

Candidate for KPro type I

Capacity to give written consent

Ability to be followed for the duration of the study

Disqualifiers

Participation in another interventional study

Failure to wear a therapeutic contact lens due to abnormalities of the eyelids.

Inability to give written consent

Severe dryness with keratinization of the ocular surface

Trial design

Treatments tested in this trial

  • Crosslinking with riboflavin of the corneal graft-support
  • De-epithelisation of the corneal graft support with instillation of riboflavin

Treatment groups

40 Participants
are divided into 2 treatment groups

Sponsors and collaborators