Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-90
SponsorJessa Hospital
About this trial
In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well.
The purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.
Eligibility criteria
Qualifiers
must meet the Barany criteria for bilateral vestibulopathy: bilaterally pathological horizontal angu- lar VOR gain <0.6, measured by the video-HIT5 or scleral-coil technique and/or
reduced caloric response6 (sum of bither- mal max. peak SPV on each side <6◦/sec7) and/or
reduced horizontal angular VOR gain <0.1 upon sinusoidal stimulation on a rota- tory chair (0.1 Hz, Vmax = 50◦ /sec) and a phase lead >68 degrees (time constant <5 sec).
must be 18 or older
Disqualifiers
< 18 y
does not meet Barany criteria for BV
contraindication for CT and MR imaging
Trial design
Treatments tested in this trial
- vestibular test 1
- vestibular test 2
- vestibular evoked myogenic potentials
- audiometry
- CT and MR imaging of temporal bone
- p.P51S mutation
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov