The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy. Its primary objective is to investigate whether the presence of a specific echocardiographic contraction pattern before implantation is associated with increased rates of acute improvement in myocardial function (as measured by an ultrasound) and to compare the improvement in two groups of patients based on the type of pacing (biventricular or left-sided pacing)
>18 years < 90 years
Patients with a documented indication for resynchronization therapy [symptomatic patients despite optimal medication, HFrEF (EF<35%), LBBB QRS morphology]
COMPLETE LBBB (LBBB defined as QRS>130msec, wide "notched or slurred" R wave in leads I, aVL, V5, V6 and occasional RS pattern in V5, V6, absence of Q waves in leads I, V5 and V6 but in lead aVL narrow Q wave may be present in the absence of myocardial pathology, R peak time >60ms in leads V5 and V6 but normal in leads V1, V2, V3 when small R's are discernible in precardial leads, ST and T usually opposite to QRS direction)
Patients with ntraventricular septum diameter >8 mm
Patients with RBBB or atypical LBBB QRS morphology
Patients eligible for an upgrade procedure (already carring a PM or ICD)
Patients with hypertrophic cardiomyopathy
University Hospital of Patras
Lead sponsor
University General Hospital of Heraklion
Collaborator
Ippokrateio General Hospital of Thessaloniki
Collaborator
Onassis Cardiac Surgery Centre
Collaborator
Alexandra Hospital, Athens, Greece
Collaborator
Korgialenio-Benakio Red Cross Hospital
Collaborator
Ippokration General Hospital
Collaborator