Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment
ConditionParkinson Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40+
SponsorVanderbilt University Medical Center
About this trial
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
Planned clinical electrode trajectory that contacts caudate
Age greater than or equal to 40
Diagnosis of Parkinson's disease
Disqualifiers
Age less than 40
Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
Movement disorder other than Parkinson's disease
Trial design
Design model
Single group
Treatments tested in this trial
Neurophysiology recordings
Other interventionNeurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated
Neural stimulation
Other interventionNeural stimulation will be delivered during a gambling task and its impact on task performance quantified
Treatment groups
75 Participants
are divided into 1 treatment groupGroup A: Neural recordings and stimulationExperimental treatment 2 interventions
Trial outcomes
Primary outcomes
1
Changes in caudate DLPFC beta coherence
Caudate DLPFC coherence will be computed at rest and during the gambling task and correlated with cognitive metrics
Time frame
Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours2
Changes in gambling task performance with neural stimulation
The gambling task will involve seeing a series of cards presented on the screen and pressing a button to respond with a bet. Gambling task performance will be compared between stimulated and non stimulated blocks and between stimulation targets
Time frame
Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hoursSecondary outcomes
1
Change in beta power with neural stimulation
Beta power will be computed and compared between stimulation on and off conditions for different targets
Time frame
Baseline to end of deep brain stimulation (DBS) surgery, approximately 3-4 hoursSponsors and contacts
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Source ClinicalTrials.gov