Creatine and Perioperative Brain Health
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-75
SponsorMassachusetts General Hospital
The goal of this study is to understand the effects of oral creatine supplementation in the perioperative period. Creatine is commonly used to enhance athletic performance, but it can also have positive effects on the brain. Since surgery can lead to alterations in thinking, memory, and attention patterns in some patients, we will assess whether creatine can be protective against these changes in older adults undergoing surgery.
Patients scheduled for elective surgery under general anesthesia
History of creatine deficiency disorders
Severe neurologic or psychiatric diseases
History of stroke or head trauma
Obesity (BMI ≥ 30 kg.m-²), kidney or liver disease