Creatine and Perioperative Brain Health
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-75
SponsorMassachusetts General Hospital
About this trial
The goal of this study is to understand the effects of oral creatine supplementation in the perioperative period. Creatine is commonly used to enhance athletic performance, but it can also have positive effects on the brain. Since surgery can lead to alterations in thinking, memory, and attention patterns in some patients, we will assess whether creatine can be protective against these changes in older adults undergoing surgery.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Patients scheduled for elective surgery under general anesthesia
Disqualifiers
History of creatine deficiency disorders
Severe neurologic or psychiatric diseases
History of stroke or head trauma
Obesity (BMI ≥ 30 kg.m-²), kidney or liver disease
Trial design
Design model
Single group
Treatments tested in this trial
Creatine monohydrate
Dietary supplementParticipants will receive creatine supplementation before surgery
Treatment groups
80 Participants
are divided into 1 treatment groupGroup A: Patients under creatine monohydrate interventionExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Preoperative cognitive function assessed with the Montreal Cognitive Assessment (MoCA)
The MoCA is a validated tool to assess cognitive function. Scores range from 0-30, with higher scores representing better cognitive function
Time frame
Within three weeks before surgery2
Postoperative cognitive function assessed with the Montreal Cognitive Assessment (MoCA)
The MoCA is a validated tool to assess cognitive function. Scores range from 0-30, with higher scores representing better cognitive function
Time frame
Within one month after surgery3
Postoperative cognitive function assessed with the Montreal Cognitive Assessment (MoCA)
The MoCA is a validated tool to assess cognitive function. Scores range from 0-30, with higher scores representing better cognitive function
Time frame
Within three months after surgery4
Postoperative delirium assessed with the Confusion Assessment Method
The CAM is a validated tool to detect postoperative delirium
Time frame
Up to 7 days after surgeryLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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