About this trial
Thunderstorm asthma is a recurring public health emergency in South-Eastern Australia which occurs in springtime. The major identified risk factors for thunderstorm asthma is hay fever and allergy to ryegrass pollen. The goal of the CARISTA study is to identify the risk of springtime allergic and thunderstorm asthma in allergic adults living in South-Eastern Australia. To do this the investigators will recruit 530 people who have hay fever and test them for allergy to ryegrass pollen and undertake simple lung function testing. The investigators will ask study participants to complete a customised symptom tracker over the springtime pollen season for 2 consecutive years. The outcome the investigators are looking for is an asthma exacerbation or worsening asthma symptoms. This study will enable the investigators to identify indicators (biomarkers) of severe and moderate asthma exacerbations in order to identify those at risk of thunderstorm and seasonal asthma so protective treatments and strategies can be advised.
Eligibility criteria
Qualifiers
Lung function testing
Blood sample collection for risk factor identification, -Prospectively logging their symptoms and medications through the springtime season using the CARISTA symptom monitoring platform . -
Disqualifiers
Individuals unable to provide informed consent
Individuals who do not suffer from symptoms of seasonal allergic rhinitis
Individuals who do not consent to lung function testing and blood sample collection - Individuals with unstable asthma (FEV1 by spirometry less than 70% predicted), a recent exacerbation or change of asthma preventive medication use (within one month) would be excluded, although re-screening would be permitted after one month, time permitting.
Individuals with severe asthma requiring the use of continuous oral corticosteroids or biological medication for severe asthma.
Trial design
Treatments tested in this trial
- Observational
Treatment groups
Sponsors and collaborators
University of Melbourne
Lead sponsor
The Alfred
Collaborator
Eastern Health
Collaborator
Austin Hospital, Melbourne Australia
Collaborator
Monash Medical Centre
Collaborator
Queensland University of Technology
Collaborator
Northern Hospital, Australia
Collaborator
Western Hospital, Australia
Collaborator
Melbourne Health
Collaborator