Crystalloid vs Colloid for Hemodynamics During Anesthesia Induction in TAVR Patients
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAir Force Military Medical University, China
About this trial
The purpose of this study is to evaluate whether the administration of 5 ml/kg of colloid solution prior to anesthesia induction, compared with 5 ml/kg of lactated Ringer's solution, can reduce hemodynamic fluctuations during the induction period (defined as the first 15 minutes after induction) in patients undergoing Transcatheter Aortic Valve Replacement (TAVR).
Eligibility criteria
Qualifiers
Age ≥ 18 years;
Patients scheduled to undergo elective TAVR under general anesthesia;
Disqualifiers
Allergy to hydroxyethyl starch, its components, and/or sodium lactate Ringer's solution, or a history of colloidal allergy;
Severe cardiac dysfunction (ejection fraction[EF] < 35%);
Severe renal dysfunction (creatinine > 132 μg/L and/or requiring renal replacement therapy);
Morbid obesity (body mass index[BMI] > 37.5 kg/m² or > 32.5 kg/m² with metabolic diseases);
Trial design
Treatments tested in this trial
- Hydroxyethyl starch 130/0.4
- Lactate Ringer's Solution
Treatment groups
116 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov