Individuals with substance use disorders (SUD) have to cope with drug-related cues and contexts, which can affect instrumental drug seeking as shown with Pavlovian to instrumental transfer (PIT) paradigms in animals and humans. The investigators aimed to investigate the impact of acute and chronic stress on Pavlovian-to-instrumental transfer (PIT), how PIT it is associated with cognitive control abilities and whether such effects predict losing vs. regaining control in subjects with AUD. Moreover, the investigators aimed to develop a novel full transfer task that assesses both, general and specific PIT to investigate whether specific PIT differs between alcohol use disorder (AUD) and control subjects.
males and females between 16-65 years of age
AUD subjects only: meet a minimum of 2 criteria for DSM-5 alcohol-related disorder (AUD) (not requiring withdrawal as assessed by an independent psychiatrist) and AUDIT > 4
Smokers: Daily smokers only: smoke 7 days/week during the last three months
Non-daily smokers only: smoke at least once but less than 7 days/week during the last three months
Lifetime diagnosis according to DMS-5 for: Bipolar disorder, schizophrenia, schizophrenia spectrum disorder, substance dependence except for alcohol, nicotine, or cannabis
Currently meeting DSM-5 diagnostic criteria for a depressive episode, suicidal ideation
Past traumatic brain injury or severe neurological disease (such as dementia, Parkinson's disease, multiple sclerosis)
Pregnancy or breastfeeding
Charite University, Berlin, Germany
Lead sponsor
Technische Universität Dresden
Collaborator