Cytokine Expression in Psoriasis Patients With and Without Joint Involvement
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-100
SponsorPoitiers University Hospital
About this trial
The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence or absence of joint involvement. This research will compare cytokines levels in sera, in PBMC culture after LPS or CD3/CD28 agonist antibodies, and in skin biopsy.
Eligibility criteria
Qualifiers
Age over 18 years old
Signed informed consent
5 year old psoriasis at least
At least one skin lesion over 2 cm
Disqualifiers
Joint damage according to CASPAR criteria
Echography activity in favor of chronic inflammatory rheumatism
Without social protection rights
People under judiciary protection, of less than 18 years old, pregnant woman, breast feeding women, jailed patients.
Trial design
Treatments tested in this trial
- Blood sample collection
- Skin sample collection
Treatment groups
40 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov