The purpose of this study is to examine the impact of early surgery in patients with asymptomatic severe aortic valve stenosis with signs of subclinical LV dysfunction despite preserved LVEF, with a watchfull waiting approach.
1. Severe AS defined as
aortic valve area (AVA) ≤1 cm2, AND
Transvalvular maximum velocity (Vmax) ≥3.5 m/s AND
AS severity evaluated severe by a heart valve team conference. In cases where severity is not unambiguous an integrative approach will be utilized combining echocardiographic markers of valve severity and LV function, and if necessary aortic valve calcification estimated by non-contrast CT.
LVEF<50%
Very severe AS defined as Vmax>5 m/s.
Concomitant severe valvular disease other than AS
Previous valvular surgery
Odense University Hospital
Lead sponsor
Rigshospitalet, Denmark
Collaborator
Aarhus University Hospital
Collaborator
Aalborg University Hospital
Collaborator
Zealand University Hospital
Collaborator