About this trial
Several observations have been made with magnetic resonance imaging (MRI) that characterize brain connections and brain function in individuals with schizophrenia and other mental disorders. For example, research investigating schizophrenia focuses on the dysfunction of connections within and between the medial temporal lobe and the prefrontal cortex as well as other pertinent brain regions. This database registry will allow for the collection of clinical interview data, behavioral data, blood, magnetic resonance imaging (MRI) data, and functional magnetic resonance imaging (fMRI) data on individuals with and without mental disorders to better understand how connections in the brain and various brain regions function differently while volunteers perform various cognitive tasks. This is an observational study that is being conducted to collect data and place it in a registry for current and future investigational questions related to imaging in mental disorders.
Eligibility criteria
Qualifiers
Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) diagnosis of Schizophrenia or Schizoaffective disorder
Competent to give informed consent
All races and ethnicities
Eyesight corrected to 20-40 or better
Disqualifiers
Diagnosis of an organic brain disease
Diagnosis of DSM-IV-TR alcohol or substance abuse within the last month or DSM-IV-TR alcohol or substance dependence within the last three months
Serious, unstable medical illness
History of serious head injury
Trial design
Treatments tested in this trial
- Not listed
Trial groups
Sponsors and collaborators
University of Texas Southwestern Medical Center
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator