Phase 1 objective: test the feasibility of using a 3Tesla MRI scanner instead of a 7Tesla MRI scanner to measure brainstem responses to LBNP in healthy participants.
Phase 2 primary objective: compare the brainstem responses to LBNP in patients with PD associated with OH to PD patients without OH using BOLD fMRI
Signed informed consent
Age ≥ 18 years and <75 years
Normal office blood pressure (<140/90 mmHg)
For women of childbearing potential: using or willing to use during the study a reliable contraception method compatible with MRI
Schellong test showing OH (drop of Systolic BP >20 mmHg or Diastolic BP >10 mmHg)
Pregnant or lactating women
Refusal to be informed of incidental findings
Any medication (acute or chronic prescription) except oral contraception
Centre Hospitalier Universitaire Vaudois
Lead sponsor
Ecole Polytechnique Fédérale de Lausanne
Collaborator
University Hospital, Geneva
Collaborator