Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles
ConditionMemory, Delayed
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of California, Los Angeles
About this trial
The proposed project seeks to elucidate memory processes and consolidation during sleep by leveraging the unique capability of direct recordings from the human brain at multiple levels of resolution-single neurons, localized neuronal assemblies, intracranial local field potentials-during rich behavioral tasks with real-life narratives and extracting neural features that relate to different aspects of episodic experience. The investigators will further probe causal mechanisms of consolidation by application of auditory and electrical stimulations during sleep and its effect on modulating memory processes.
Eligibility criteria
Qualifiers
All epilepsy patients between the ages of 18 and 65 who undergo depth electrode placement for clinical purposes
Eligibility is determined by the epilepsy surgery team (based on neuropsychological testing and on psychiatric evaluation)
Willing to provide informed consent and participate the study
Disqualifiers
Neurological or psychiatric issues, other than epilepsy, that would put the patient at risk
Patient is younger than 18 or older than 65 years of age
Unwilling to provide informed consent
Trial design
Treatments tested in this trial
- Auditory and Electrical Stimulation
Treatment groups
No treatment groups listed
Sponsors and collaborators
University of California, Los Angeles
Lead sponsor
University of Iowa
Collaborator
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
Source ClinicalTrials.gov