Deep Brain Stimulation for Laryngeal Dystonia: From Mechanism to Optimal Application
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-70
SponsorIndiana University
About this trial
Deep Brain Stimulation (DBS) is a neurosurgical procedure used to treat tremors, and dystonia. This study will enroll people who have a form of focal dystonia that affects their vocal cords called Adductor Laryngeal dystonia (ADLD). Participants will undergo Deep Brain Stimulation surgery to treat laryngeal dystonia as part of their clinical care. Before surgery, as part of the study they will have specialized testing to study the movement of the vocal cords, as well as functional magnetic resonance imaging (fMRI). While in the operating room, researchers will examine brain waves to better understand how faulty brain firing patterns lead to dystonia. After surgery, and activation of the deep brain stimulator, participants will repeat speech testing and vocal cord imaging as well as magnetic resonance imaging (MRI).
Eligibility criteria
Qualifiers
Patients with ADLD and ADLD plus tremor, as diagnosed by routine clinical examination by laryngologist, speech language pathologist, and neurologist.
Patients undergoing globus pallidus interna (GPi) deep brain stimulation (DBS) for ADLD with tremor
Age range of 18-80 years
Native speakers of American English will be recruited since there are known differences in voice and neural signals of native and non-native speakers
Disqualifiers
Individuals younger than 18 years and older than 80 years of age.
Women who plan to become pregnant during the study period or are currently breastfeeding.
Prior history of stroke, brain surgery, or other neurological disorder besides the one under study.
Prior laryngeal framework surgeries or other disorders affecting the vocal folds
Trial design
Treatments tested in this trial
- Deep Brain Stimulation
Treatment groups
12 Participants
are divided into 1 treatment groupSponsors and collaborators
Indiana University
Lead sponsor
National Institutes of Health (NIH)
Collaborator
Source ClinicalTrials.gov